Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 The current concept of development of specialized intercellular connections between cardiomyocytes Сучасна концепція розвитку спеціалізованих міжклітинних з'єднань кардіоміоцитів 6 15 UK N. S. Petruk I. V. Tverdokhleb 2009 7 12 2009 8 22 The understanding of development of interrelation between electric and mechanical contacts in ontogenetic aspect can throw light on the mechanisms underlying heart pathologies related with local disturbance of gap junctions distribution. Despite of significant progress in understanding of structural biology of desmosome, fascia adherents and gap junctions which are a part of an intercalated disk, the detailed characteristic of interrelation between electric and mechanical connections it is not presented still now in the literature. So, data about formation, becoming, development and regulation of specific pattern of intercellular connections remain fragmentary and do not allow to make complete representation about ontogenetic features of formation of communicative contacts between cardiomyocytes. Understanding of development of an intercalated disk young heart, are important for optimization of terms of surgical intervention in pediatrics in occasion of congenital heart diseases. On the other hand, changes of the organization of intercellular contacts, first of all gap junctions, can lead to abnormal conductivity and arrhythmogenesis. Knowledge of similar aspects of development arrhythmias can push to development of new therapeutic methods which will provide higher efficiency of treatment at, for example, ischemic illness of heart or intimate insufficiency.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Age anatomy of human nasal septum Вікова анатомія носової перегородки 16 20 UK N. R. Yemelianenko 2009 8 12 2009 9 23 A bibliographical analysis of recent scientific publication deals with a topical problem of modern otorhinolaryngolology – age anatomy of human nasal septum. In its anatomic structure the nasal cavity is one of the most difficult structures of human organism. An important structure, which control the aerodynamics of the air-stream, provides the heating, wetting and cleaning of air, regulates in a definite way the hormonal balance of the whole organism, is the nasal septum. Plenty of scientific publications on this issue testify to the personal interest of the whole world scientists in these question. At the same time a general idea absents in relation to an anatomic structure, becoming, development, functioning, sexual-age-old changes of nasal septum, etiology and pathogenic of its most widespread diseases and choice of optimal methods of their correction. During the human development the nasal septum undergoes substantial changes. So in new-born the medial wall of nose is formed by a cartilaginous plate and bony vomer, which shows by itself two bony plates which engulf the lower edge of cartilaginous plate of nasal partition. On this stage of ontogenesis the processes of ossification of structures of nasal partition last yet. To it testifies circumstance that clear anatomic borders between the perpendicular plate of ethmoid bone and cartilage of nasal partition in new-born are impossible to set. Consequently, the analysis of scientific literature certifies that present information, in relation to the age anatomic features of nasal partition and character of its blood supply is fragmental and incomplete. It specifies on the necessity of lead through of their more complete research and systematization of findings.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Rearrangement of rat kidney sialoglycans during postnatal morphogenesis and in streptozotocin-induced diabetic nephropathia Перебудова сіалогліканів нирки щура у постнатальному морфогенезі та при стрептозотоцин-індукованій діабетичній нефропатії 21 31 UK N. O. Ambarova 2009 8 18 2009 9 26 9 lectins with different carbohydrate affinities (SNA, WGA, RCA, PNA, VAA, CABA-2, SJA, SBA, HPA) were used for histochemical investigation of rat kidney glycoconjugates during postnatal morphogenesis and in streptozotocin-induced diabetes mellitus. Tissue samples were fixed in 4% neutral formalin and embedded in paraffin. Carbohydrate determinants labeled with lectin-peroxidase conjugates wеre visualized by diaminobenzidine. Postnatal morphogenesis was accompanied by enhanced sialic acid and reduced DGal/ DGalNAc expression, increased heterogeneity of kidney components. On postnatal day 60 was revealed selective labeling of renal corpuscles, tubules of outer medulla with WGA and RCA, and of cortical tubules with SBA and HPA, these signs presumably witnessing organ maturation. Development of diabetic neph-ropathy was accompanied with the accumulation of glycoconjugates with terminal DGal/ DGalNAc and reduced sialoglycan contents, increased labeling of renal tubules brush border with specific lectin markers.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 The peculiarities of vascular-capillary bed formation of the cardiac conduction system in pre- and early postnatal ontogenesis Особенности становления сосудисто-капиллярного русла проводящей системы сердца в пре- и раннем постнатальном онтогенезе 32 36 RU V. N. Antipov 2009 8 26 2009 9 17 The research purpose was to establish the features of structural organization of hemomicrocirculatory vessels in a human cardionector in early ontogenesis, to expose the degree of correlation of morphometric parameters of CCS and being alongside retractive myocardium. On 26 foetuses and under 3 years old children’s hearts the histostructural peculiarities of hemomicrocirculation vessels formation in the cardiac conduction system and nearby myocardium were considered. It has been determined that the formation of hemomicrocirculatory vessels takes place in two stages – intertrabecular and extracar-dial, each corresponding to transition from histotrophic to hemotrophic feeding types. It has been established that apart from simultaneous development and functioning of cardiac conduction system and contractive myocardium their hemomicrocirculatory vessels differ both in location and in morphology. The circulatory system of CCS in early postnatal ontogenesis has the same structural elements of hemomicrocirculatory vessels mainly, as well as in retractive myocardium. Along with the proc-esses of formbuilding in the about-leading system after birth, by a compression and interlacing of conducting myocytes, their compactisation, the hemomicrocirculatory vessels acquire a net-form spatially, and the vessels of a special form – sinusiod veins – appear here. The analysis of specific volume of hemomicrocirculatory vessels rotined that AVP, its perforation part, has the least intensive bloodsupply, and, taking into account that it same the bottleneck of atrio-ventricular department of CCS, the insignificant diminishing of blood stream in it or sclerotic processes in a central fibrous body can influence on forming of arhytmhogeny heart.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Application of the cytochemical and cytologic methods in diagnosing and preventive treatment of generalized periodontitis in patients suffering from bronchial asthma and receiving glucocorticosteroid therapy Використання цитохімічного та цитологічного методів в діагностиці та превентивному лікуванні генералізованого пародонтиту у хворих на бронхіальну астму на тлі глюкокортикостероїдної терапії 37 41 UK V. M. Babenko 2009 7 12 2009 8 29 The aim of the investigation was to estimate indices of cytochemical and cytologic methods for diagnosing of generalized periodontitis and dynamic following of preventive treatment results in patients suffering from bronchial asthma and receiving glucocorticosteroid therapy. The results of studying 117 patients with generalized periodontitis (95 patients suffering from generalized periodontitis and bronchial asthma; 22 patients in the group for comparison) showed that the level of cuccinatedehyrogenase and ά-glycerophosphatdehyrogenase alters according to the clinical course of generalized periodontitis, wich allows to objectively evaluate treatment efficaly and completeness of arresting the inflammatory process in the parodontium. It was proved that cytochemical changes and cytologic picture correlate with severity of generalized periodontitis in patients suffering from bronchial asthma and receiving glucocorticosteroid therapy. Such changes may be used for giagnosing and dynamic follow-ing of the patients.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 New method of identification of I and III collagen types at forming fibril framework of mesonephros and metanephros of human embryos Новый подход к идентификации коллагенов I и III типов при формировании волокнистого каркаса первичной и окончательной почек у эмбрионов человека 42 45 RU T. A. Boyko Ye. Yu. Shapovalova 2009 8 17 2009 9 27 Becoming of collagen composition of fibril framework of meso- and metanephros was studied by the method of immunohistochemistry and lectinochistochemistry on 124 human embryos in age from 21 days to 12 weeks of intrauterine development. Embryos were fixed in formalin and embedded in the paraffin. Primary antibodies were monoclonal antibodies to the collagen type I and III. Lectins of Perca fluviatilis and Vica Alba were used. It is received, that collagen fibers type I were stained by lectin of Perca fluviatilis and collagen fibers type III were stained by lectin of Vica Alba. In 12 weeks em-bryo mesonephros connective tissue fibers consisted of types I and III collagen. In 12 weeks aged embryo metanephros stroma connective tissue fibers consisted of types I and III collagen. Collagen fibers of III type firstly appeared in meso- and metanephros. Type I collagen fibers are found later. The collagen fibers type I repeated a dynamics and histotopography of collagen fibers type III, but them far fewer.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Structural-functional organization of multilayered squamous epithelium of vocal сords of larynx at the persons of mature age Структурно-функціональна організація багатошарового плоского епітелію справжніх голосових складок гортані у осіб зрілого віку 46 49 UK Y. А. Gasyuk 2009 8 16 2009 9 21 On the basis of the conducted morphological researches it is set, that in cellular elements of multilayered squamous epithelium of vocal cords of larynx is observed layer stage of processes of keratinization, therefore even in a norm it has a tendency to the cornification. It physiological regeneration takes a place due to the proliferation of cells of basale layer and parallel tearing away of grainy cells. On logarithms of volume of nucleus of cellular elements of different layers of multilayered squamous epithelium make the row of differentiation: 0,75; 0,95; 1,45; 1,15 and 0,85, which corresponds the nuclearmetrical laws.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Formation of neuro-glio-capillary relation in neurohypophysis on different stages of postnatal period of ontogenesis Становлення нейро-гліо-капілярних співвідношень задньої частки гіпофізу на етапах постнатального періоду онтогенезу 50 54 O. Ja. Zhurahivska V. A. Levitskij 2009 8 25 2009 9 27 Although the row of works is devoted to ontogenesis of hypophysis, a question on what stage of ontogenesis hypothalamic-neyrohypophysal system starts its functions is rather controversial and needs subsequent study. Therefore, our purpose was to research the patterns of becoming neyro-glio-capillary correlations of the posterior lobe of hypophysis on the stages of postnatal ontogenesis. The material for research were the pieces of neurohypophysis of 40 white purebred rats of males in age: new-born, 7, 45 and 90 days after birth. At the fence of material for electron microscopic research the generally accepted rules of speed of carving are observed and not traumatic. The research of ultrastructure of neurohypophysis of white rats showed that on the first week of their life the amount of axon-vessel synapses and neurosecretory granules had increased, among which a zonality of situation of different types of them is observed, that testifies to completion of neurosecretory structures formation. Submicroscopic structure of sinus capillaries in this term specifies on their high functional activity, in particular, about an enhanceable transendothelial transport. Thus, our research allows to draw a conclusion, that already dur-ing the first week of life in the structure of neurohypophysis of rats substantial high-quality and quantitative changes take place, which testify to completion of becoming of its neurosecretory structures and on later stages of postnatal development they are only perfected.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Morphometrical indexes of supraoptic and arcuate nucleus of hypothalamus of experimental animals under harmful factors influence Морфометричні показники супраоптичного та аркуатного ядер гіпоталамусу експериментальних тварин за умов впливу шкідливих чинників 55 59 UK V. M. Zaporozhan O. L. Holodkova D. M. Pichteyev A. L. Shcherbatyuk 2009 8 25 2009 9 28 Influence of adriblastin and sodium nitrite on morphofunctional state of hypothalamus of male and female mice of ICR line is described in this article. It was observed that neurons in resting phase were prevalent in investigated nuclei of the experimental groups whereas neurons in neurosecret accumulatory phase were prevalent in the control. Index of neurose-cretory activity decreased in the experimental mice comparatively to the control, thus in groups which were injected with adriblastin it decreased to a greater degree. In female experimental groups neurosecretory activity decreased more slowly than in male. It is made an assumption that neurosecretory activity decrease of experimental group is conditional on exhaus-tion in consequence of neuromediatory effect of adriblastin and sodium nitrite.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Features of structure of skin of hairy part of head of men at androgenic defluxion Особенности строения кожи волосистого отдела головы мужчин при андрогенной алопеции 60 65 RU Yu. P. Kostilenko O. A. Tikhonova 2009 8 28 2009 9 23 Utilized by us universal innovative method of morphological researches provided the receipt of original information, which not only complement the known facts but also in more depth expose principles of device of skin of hairy part of head of men in a norm and after an androgenic pelade. In the process of androgenic pelade degradation foremost intradermal hair follicles undergo sclerosis. In the reticulated layer of derma degrading hair follicles substituted with connective tissue. Complete loss of hair at an androgenic defluxion, results in compensatory reorganization of skin of hairy part of head, which is expressed in a substitution of hypodermis connecting tissue by fatty tissue, blood vessels formation in all layers of skin of with prevaliation of venous among, and also, in the considerable increase of concentration of sebaceous glands in the reticulated layer of derma. In spite of complete loss of hair at an androgenic pelade, germ epithelial elements, being sources of formation of thin (abortive) hairsprings array patterns of which are saved in the skin of hairy part of head, hidden in the layer of sebaceous glands. On the basis of the actual findings in our work revealed, that loss of hairs at an androgenic defluxion filled in due to the physiological hypertrophy of other tissue constituents of skin.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 The development of intervertebral disks during an early period of human ontogenesis Розвиток міжхребцевих дисків у пренатальному періоді онтогенезу людини 66 69 UK V. V. Kryvetskyi I. I. Kryvetskaja 2009 8 21 2009 9 23 Deviations in forming and development of axial skeleton, even if they appear in the postnatal period of ontogenesis, but do not have clinical displays, may be considered as a basis of future pathology of spine of the adult. Their timely surgical removal or complex of conservative measures allow to correct the processes of development and growth, improve the health of grown-up population. Research purpose was to learn the development and becoming of intervertebral disks in the prenatal period of ontogenesis of man and their anatomic features at new-born.The terms of the enlarge of the intervertebral disks, the peculiarities of the development, differentiation of their cells, fibers and vessels have been elucidated by means of the microscopy methods of serial histological sections of 65 spine specimens on the site of the spine column of embryos, prefetuses and 45 fetuses and human neonates. Research conclusions: 1. At the end of early period of ontogenesis basic structural components of disk are determined. 2. There are dense fibred plates of fibrous ring in the external area of disk, in a middle area is a fibrous cartilage, and a gel kernel is formed in a center. The external s more differentiated dense fibred tissue and fibrous cartilage provide the dense attaching of disk to the bodies of vertebrae, and the less differentiated, but resilient tissue of gel kernel provides a spring function of disk.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Influence of human embryos ectopic implantation on intercellular adhesion formation of epithelium and mesenchyme germ cells of pancreas Влияние эктопической имплантации зародышей человека на особенности межклеточной адгезии клеток эпителиальных и мезенхимных закладок поджелудочной железы 70 74 RU N. I. Majstruk E. Yu. Shapovalova 2009 9 2 2009 9 28 In 122 human embryos in the age from 21 day to 12 weeks of the intrauterus development at absence of the obviously expressed damaging factors of external environment, which includes stage X - XXIII and beginning of the fetal period by classification of Carnegie institute and in 42 embryos of tubal pregnancy, regularity of glycopolymers redistribution in pancreas epithelial and mesenchymal germs have been revealed. Manosoconjugates of the cells and extracellular matrix have been identified by lectin of Lens culinaris. At typical implantation manosoconjugates are connected to cell to cell adhesion. At tubal implantation the process of adhesion changes. It is correlated with decreasing of manosoconjugates biosynthesis.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Formation of physiologic atresia in combination with development of esophageal epithelium Формування фізіологічної атрезії в поєднанні з розвитком епітелію стравоходу 75 78 UK F. D. Marchuk Yu. T. Akhtemiichuk B. G. Makar O. P. Antoniuk 2009 8 25 2009 9 28 In five weeks embryos as a result of the active proliferation of epithelium of esophageal mucous membrane occurs so-called physiological atresia of organ. Epithelium of the mucous membrane and esophageal glands has entodermal origin. In 6-7-weeks embryos structural changes in epithelial esophageal layer were observed. At the end of the embryonic period the differentiation of mesenchimal cells which surrounding of esophageal mucous membrane are taking place, some of them are lengthening and located concentrically, which should be consider of the beginning of circular layer of the esophageal mucous membrane. In prefetuses of 45,0-50,0 mm PCL (10-th week) esophageal mucous membrane is represented mainly by two-layered cylindrical epithelium. Recanalization of the esophageal gap begins and ends in prefetuses of 7-10 weeks.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Chemical homeostasis of thyroid gland under modelling microelementosis influence Хімічний гомеостаз щитоподібної залози під впливом модельованого мікроелементозу 79 83 UK R. A. Moskalenko 2009 8 12 2009 9 27 The work presents the results of the research of a thyroid tissue of 36 laboratory rats of different ages which have been drinking water with salts of zinc, cooper, iron, manganese, chrome and lead within 60 days. By means of anatomical, histological and spectrochemical methods it was established: the most significant morphological changes was increase with the growing terms of the experiment, concentration of ions in 30 days of experiment was the highest in the thyroid gland of young aged rats, at the end of the experiments the decreasing of the speed of their accumulation was observed. This work consideres the influence of ions of heavy metals on apoptosis of thyrocytes.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Age morphofunctional features of organs and systems of organism under different gravitational overload influence and different methods of their correction Возрастные морфофункциональные особенности отдельных органов и систем организма под влиянием различных гравитационных перегрузок и различных методах их коррекции 84 89 RU V. S. Pikalyk S. A. Kutya G. A. Moroz I. A. Verchenko T. S. Shumkus G. R. Adzhusaliev A. Yu. Sherbina 2009 9 7 2009 9 29 Age features of a structure and function of separate organs and systems of an organism were investigated under effect of gravitational overloads, and also efficiency of protection methods of various nature. Age features of a morphgenesis of bone system, lungs, stomach, myocardium, thymus gland, spleen, suprarenal glands, cellular and biochemical composition of blood are established under effect of gravitational overloads in experiment. Morphological proofs of effectiveness of methods of stability augmentation to gravitational overloads, namely physical, pharmacological (application of domestic medicines Glutarginum and Lipoflavon) and their combinations are received.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Mineral exchange in traumatic bone in normal condition and under water-salt balance disturbance Мінеральний обмін травмованої кістки в нормі та при порушенні водно-сольового балансу 90 94 UK M. V. Pogorelov 2009 8 10 2009 9 16 In this article has been studied chemical compound of the tibia regenerate in normal condition and during the overhydratation on the adult rats. The dates that we found showed the increase of the mineral substances and Ca and decrease of the water, Fe, K and Na. Also the level of Mn and Zn increase in second stage of bone repair processes but Cu – in last term of research. Overhydratation make a disorder of chemical compound (increase the level of Ca and disorders of the macro- and microelements metabolism).

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Histomorphological changes in thymus and spleen after cyclooxygenase inhibitors treatment Гістоморфологічні зміни тимуса та селезінки під впливом інгібіторів циклооксигенази 95 101 UK N. O. Poeta A. A. Gorbunov V. Yo. Mamchur 2009 6 14 2009 8 23 The influence of cyclooxygenase inhibitors on the lymphoid organs histomorphology has been examined in the matured outbread white mice. Diclofenac, meloxicam, celecoxib, but not rofecoxib has shown depressive action on the im-munocompetetive organs histomorphologic structure. Macroscopic study has revealed a decrease in the weight of the spleen and thymus. Light microscopy has shown a decrease in the number of thymocytes, due to degradation of cortex area. In the lobular medulla it has been observed microcirculation changes in the view of venules and capillaries distention, arteriolar wall thickening. In the spleen it has been shown a decrease in the white pulp volume, disappearing of the reactive centers in follicles. Also subcapsular edema and relative stroma volume increase has been seen frequently. The use of highly selective COG-2 inhibitor rofecoxib has not revealed statistically truthful changes in microscopic examination in comparison to the control group. That could vote for the absence of depressive action on the immune organ histomorphologic structure.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 APUD-cells of prostate in dark-cell adenocarcinoma Апудоцити передміхурової залози при темноклітинних аденокарциномах 102 107 UK O. V. Prokopyk O. G. Kurik 2009 7 20 2009 9 7 A research purpose was a quantitative and qualitative study of prostatic APUD-cells at dark-cell adenocarcinoma. The histochemical and morphometrical investigation of APUD-cells of prostate with dark-cell carcinoma, prostate with hy-perplasia and normal prostate (control group) was performed. It has been revialed that the number of endocrine in dark-cell adenocarcinoma reliable increases comparative normal and hyperplasia.The number of APUD-cells was reliable decrease in poorly differentiated adenocarcinoma comparative with moderately differentiated adenocarcinoma.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 The stages of atrioventricular bundle formation in the human embryonic heart Етапність гістогенетичних перетворень передсердно-шлуночкового пучка в ембріональному серці людини 108 115 UK Yu. V. Silkina 2009 7 22 2009 8 27 The origin, stages and histogenetic processes in atrioventricular bundle were investigated. We studied the human embryonic heart from 5 to 12 week of development. Antibodies to neurofilaments, Ki-67, MSA, α-SMA and neuregulin were used. Formation of the primordia of the atrioventricular bundle depends on the chamber formation in early heart. The first morphologic reconstruction in the atrioventricular bundle starts from 5 week of gestational age. In this time we studied proximal and distal primordias, which formed general tract at 7 week. The early human heart was characterized by strong connections with atrioventricular fibrous tissue, left and right septal cuspes of mitral and tricuspidal valves. Formation of the atrioventricular bundle branches has two stages: primary and repeated growth. Median fibers are blind-ended. We suppose that atrioventricular bundle and bundle branches have extracardiac origin. Histogenesis of the atrioventricular bundle contin-ues after 12 week of human development.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 The р53 expression in cells of marginal zone of duodenal ulcers during acute bleeding Экспрессия р53 в клетках краевой зоны язвенных дефектов двенадцатиперстной кишки при остром кровотечении 116 119 RU O. N. Sulayeva E. F. Barinov L. N. Ignatyeva K. V. Baranova 2009 6 4 2009 7 15 The aim of the work was to estimate the intensity and tissue distribution of proapoptogen p53 expression in duodenal mucosa in patients with acute bleeding caused by peptic ulcers. In 31 patients (1st group) the healing of ulcer was detected after effective endoscopic hemostasis and in 15 patients rebleeding took place (2nd group). Performed immunocytochemical investigation allow to determine that acute ulcer bleeding was associated with activation of marginal zone cells apoptosis which was maximal in covering epithelium, vascular endothelium and regions infiltrated by lymphocytes. In patients with rebleeding the higher values of р53 expression were detected in crypts epithelium and in endothelium of dilatating vessels accompanied with intensive edema and lymphocytes infiltration of lamina propria and muscularis mucosae with perifocal activation of cells death. Additionally to apoptosis in 2nd group duodenum the necrosis of cells and epithelium desquamation were found, reflecting the tissue disintegration of duodenal mucosa.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 The role of medical genetic consultation in Daun disease diagnostic in 2007-2008 years Роль медико-генетичного консультування в діагностиці хвороби дауна за 2000-2008 роки 120 125 UK О. К. Tolstanov 2009 7 11 2009 8 19 The analysis of the cases of Down's disease was made among the newborn babies of Zhytomyr region for the period from 2000 till 2008 due to the using of the special computer program "Regional List of the Congenital Development Defects". This program provides the analytical work on preventing and early diagnosing of the congenital pathology. It was established that there was no relation between the effects of the ionic radiation on the chromosome pathology developing of those women's, who live on the polluted territories after the Chernobyl Nuclear Disaster. At the same time, it was noted a valuable contribution of the everyday and production teratogens, the infectious factors, the older age of women, who gave the birth to the children with Down's disease. In connection with the received information, there were determined the problems in organizing the work on selecting and hospitalizing the pregnant women from the groups of the high risk to the establishments of the III-rd level of providing medical care for making special analysis on the markers of chromosome and congenital pa-thology, with the help of which the early diagnosing of the congenital and chromosome pathology is possible.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Regional heterogeneity of mesenchyme in prostate morphogenesis for example the fetal development of human and rat Региональная гетерогенность мезенхимы в процессах морфогенеза предстательной железы у плодов человека и крысы 126 130 RU B. V. Trotcenko I. A. Lugin 2009 8 21 2009 9 23 The studies used the prostatic specimens of the humans and rats fetuses for examination the regional differentiation of mesenchyme during prostatic organogenesis. Fixed, that morphogenesis of vascular endothelium of microcirculatory bed in prostate gland during prenatal development have been illustrated by the general laws of morphological transformations in mesenchymic derivatives which is result of interaction between epithelial, stromal and vascular components during formation of functional prostatic units in ontogenesis. The maine law is the mechanism of formation of haemocapillaries by as result of aggregation the clusters of cells in mesenchyme with formation of intercellular channels which is lined flattened primary endothelial cells with continues differentiation of the future vessels during development of prostate gland. The vascu-logenesis in prostate gland is unequal and аsinchronic process wich is depended from regional organization of the prostate gland that is evidenced to stromal hypothesis, in which localized areas of stroma perform different functions in regulating epithelia.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence Лектиногистохимическое исследование эмбриогенеза легких и почек крыс, протекаю-щего в условиях отсутствия видимых повреждающих факторов и под влиянием парацетамола и нимесулида 131 135 RU S. V. Kcharchenko Ye. Yu. Shapovalova 2009 9 5 2009 9 23 467 rat embryos in the age from 13 to 22 day of the intrauterine life without visible damaging factors and under the influence of a therapeutic, subtoxic, toxic dose of paracetamol and nimesulide were investigated. Glycopolymers have been identified by three lectins, conjugated with peroxidase of horse-radish. It is established, that in cells and extracellular matrix of developing rat lungs and definitive kidney of control group contain peanut, soya and ricina glycopolymers. In process of control group rat lungs and definitive kidney embryogenesis there is constant lectin-receptor system redistribution. Paracetamol and nimesulide ingestion to pregnant rats leads to the redistribution of glycopolymers quantity and histotopogra-phy – receptors of soya, peanut and ricina lectins, changed in comparison with norm. Therapeutic and toxic dose of paraceta-mol and a toxic dose of nimesulide most strongly change histotopography and the quantity of lectins soya, peanut and ricina receptors in lungs. In definitive kidneys the therapeutic dose of paracetamol and a toxic dose of nimesulide has similar influence.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Sоmato-visceral correlation of the sphincter apparatus of the extrahepatic bile ducts in the second trimester of human intrauterine development Сомато-вісцеральні кореляції сфінктерного апарату позапечінкових жовчних проток у другому триместрі внутрішньоутробного розвитку людини 136 141 UK O. V. Tsyhykalo 2009 8 17 2009 9 13 Seventy two unfixed bodies of 4-6-month old human fetuses have been studied by means of a complex of methods of a morphologic research (somatoscopy, anthropometry, contrast radiography) and a statistical analysis. It has been established that during the second trimester of the intrauterine development a tendency towards a lover skeletopic position and the larger diapason of the individual position of the sphincter components of the extrahepatic bile ducts (EBD) in the fetuses of male gender is traced compared with the fetuses of the female gender of the same parietocalcaneal length. The skeletopy of the sphincter components of the EBD reliably correlates with the somatotype of the fetuses. Asymmetric dynamics of changes of the skeletopy of the sphincter components of the EBD is traced in the fetuses from the beginning of 6th month of development and depend on the somatotype of fetuses. The periods from the end of the 4th and to the beginning of the 5th months and the beginning of the 6th month may be considered to be critical in the development of the sphincter components of the EBD as a time of appearance of variants of its structure and a feasible appearing of malformations.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Immunohistochemical and ultrastructural characteristics of results of surgical treatment of patients with ІІІ degree chronic ischemia of lower limb Імуногістохімічна та ультраструктурна характеристика результатів хірургічного лікування хворих з хронічною ішемією нижньої кінцівки ІІІ ступеня 142 153 UK V. M. Shkuropat I. V. Tverdokhleb M. F. Drjuk 2009 6 28 2009 8 7 The purpose of research was the immunohistochemical and ultrastructural analysis of anterior tibial muscle in patients with ІІІ degree chronic ischemia of lower limb after direct, indirect and composite revascularization in near-term and long-term postoperative periods. Patients have been divided into three groups: 1) 37 patients after femoral-tibial reconstruction; 2) 57 patients after indirect revascularization with autotransplantation of bone marrow; 3) 50 patients after composite revascularization of distal part of lower limb. The observation was carried out in the near-term postoperative period and in 2 years. Immunohistochemical investigation of markers VEGF and CD34 expression and ultrastructural study of tissue sam-plings of anterior tibial muscle taken between superior and middle one thirds was carried out. It have been determined that direct revascularization causes the significant improvement in immunohistochemical characteristics of anterior tibial muscle on VEGF and CD34 expression both in ultrastructure of muscle fibers in all age groups during 6 months after operation, however does not provide the stabilization of positive changes in long-term postoperative period. Indirect revascularization does not change significally structurally-functional condition of components of muscle in near-term postoperative period, however causes the stable normalization of parameters of tissue components due to initiation of neovasculogenesis at patients till 75 years. Composite revascularization allows to receive near-term normalizing effect concerning the studied immunohistochemical and ultrastructural criteria and to provide its stabilization in the long-term postoperative period.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Immunohistochemical profile in estimation of biological properties and prognosis of breast cancer Імуногістохімічний профіль в оцінці біологічних властивостей та прогнозу перебігу раку молочної залози 154 162 UK I. S. Shponka V. A. Bondareva V. I. Shponka 2009 6 23 2009 8 3 The prognostic value of markers of biological properties of breast cancer (BC), their age-dependent and mutual correlations are finally not determined. The purpose of our study was to determine the dependence of expression of prognostic markers (ER, PgR, HER-2/neu, pS2, р53, VEGF, Кі-67, bcl-2) on age and presence of metastases at BC in women, to find the cross-correlations in groups with and without metastases. From data of statistical analysis (criterion of χ2), all of markers are thought to be used as prognostic of metastasis risk with the high level of reliability at patients of different age. The exceptions were ER and PgR in group before 35 years, ER - in group 35-50 years. Only for the ER and PgR an increase of expression with age was observed: for expression of ER a difference was reliable in groups 35-50 and above 50 years, in groups before 35 years and after 50 years; for PgR - between groups 35-50 years and above 50 years. The expression of markers of р53 and Кі-67 showed the reliable difference in groups with the presence of metastases, regardless of age. The last are most reliable as prognostic for the group before 35 years. Cross-correlations between expression of markers which depended on age and/or metastasis were determined.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Тhe variant of anomaly of the 7th month fetus’s intestines Варіант аномалії кишечнику 7-місячного плода 163 165 UK Yu. T. Achtemijchyk T. V. Hmara D. V. Pronyaev 2009 8 14 2009 9 19 Sometimes it is hard to conduct a limit between variants and defects of development an intestine. Attention of child's surgeons is directed for development of new methods of treatment of congenital defects, particularly anomalies of intestine turning (uncompleted turning, late stop of turning, reverse turning, hernia of umbilical rope), anomalies of development of bowel (imperforations, stenosises, doublings, megacolon, distributions), anomalies of the completed turn, an intestine (absence shrivels, anomalies of mesentery of different parts an intestine, common mesentery). Intestinal anomaly which can be attributed to anomalies of intestinal rotation was revealed in a 7 month old fetus. The small intestine was located in the right part of the abdominal cavity, while the large intestine – in the left part. Sigmoid colon is placed mainly in a right iliac fossa. A descending colon is determined within the limits of right lateral channel, directed caudally, to the left and ventrally. A transverse colon is located in lateral and infracostal areas on right, directed cranially, to the right and dorsally. An ascend-ing colon is placed in epygastric and right lateral areas, directed downwards. Consequently, in the resulted supervision only the anomalous placing of departments of the intestine takes place, without any anatomic changes. Structure of ileocecal lock-ing apparatus in this case answers age of child.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Cytological and histological characteristic of tissue structures of human maxillofacial apparatus on sixth week of embryogenesis Цито- и гистологическая характеристика тканевых структур челюстно-лицевого аппарата человека на шестой неделе эмбриогенеза 166 169 RU A. N. Barsukov E. Yu. Shapovalova G. A. Yunsi E. A. Dyachenko 2009 8 28 2009 9 24 The goal of our research was to investigate cytological and histological rearrangement in buds, which form the maxillofacial apparatus on 6th week of human embryogenesis. As a material we used human embryos 11-14 mm of parietal-coccygeal length that correspond Carnegie stage 16. Materials were fixed in 12% neutral formalin or in cold acetone and were embedded in paraffin, according to a standard method; serial sections were made of 10 mkm thickness. We observed that on 6th week of human embryogenesis in maxillofacial apparatus buds the high temps of cytological and histological rear-rangement coincides with activation of exchange processes, which directly connected with high rate of vasculogenesis in this region.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Morphology of the larynx during the prefoetal period of human ontogenesis Морфологія гортані в передплодовому періоді онтогенезу 170 173 UK O.-M. V. Popelyuk 2009 8 12 2009 9 17 Queries of practical otorhinolaryngology induce both morphologists and clinicists, study deeply and in details the structural organization of larynx. The retrospective analysis of literature testifies that information about patterns of development and becoming of topography of larynx during the prefoetal period of life is fragmental and does not expose the successive morphological changes of noted organ. In research the features of macroscopic and microscopic anatomy of larynx are studied at the human prefoetal. With the aid of morphometric methods of the investigation of larynx of thirty eight human prefoetuses (occipito-coccygeal length 14,0–80,0 mm), we have figured out that the differentiation and formation of laryn-geal development continues. The laying and formation and of the laryngeal cartilages, muscles, nerves and vessels occurs. The differentiation of vocal folds takes place. The shape of the larynx according to its structure is almost definitive.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 The syntopic peculiarities of walls of maxillary sinuses at juvenescent age Синтопічні особливості стінок верхньощелепних пазух у людей юнацького віку 174 176 UK T. V. Protsak 2009 8 21 2009 9 15 The peculiarities of syntopia of walls of maxillary sinuses were studied on twenty preparations of maxilla, skulls and cuts of head of juvenescent corps. We have figured out that in nine cases the lateral margin of superior wall of maxillary sinus was situated 2,0 – 4,4 mm medially to inferior ophthalmic fissure, and in one case it was corresponding to inferior ophthalmic fissure. On three preparations instead of canal on posterior two-thirds of superior wall, we have found infraorbital furrow, and on one preparation – the deepening of infraorbital canal in anteroposterior direction. In two cases the posterior wall adjoined the posterior cells of ethmoid labyrinth, and in one case – I was situated at a range of 9,0 mm from sphenoid sinus. The inferior wall, depending on maxillary sinus pneumatization, was situated above the inferior wall of the nose – in six cases, on the same level with it – in three cases, and below it – in one case.

Ukrainian Scientific Society of Anatomists, Histologists, Embryologists Morfologiâ 1997-9665 3 3 2009 10 27 Age-associated differences of neuronal-glial-capillary interactions in manual region of postcentral gyrus of the womеn brain Возрастные различия нейроно-глиально-капиллярных взаимоотношений мануальной области постцентральной извилины головного мозга женщин 177 181 UK O. G. Sieroukh S. Yu. Maslovsky 2009 8 26 2009 9 27 The dates about neuronal-glial-capillary interactions represents a grate interest both for morphologists and for clinical workers, which is connected with high rate of neuronal system pathologies associated with blood circulatory disturbances. The aim of this study was to analyze the glial-neuronal-capillary interactions and to establish age-associated differences in manual zone of postcentral gyrus of the women brain. As a material we used the brain, taken from the women corpses which were divided into 4 groups: 0-20 years, 20-40 years, 40-60 years, 60 and older. The material was dehydrated, embedded in paraffin, sliced and stained according to a standard procedures. The features of neuronal-glial-capillary interactions in manual region of postcentral gyrus of the womеn brain were studied. Age peculiarities of cell composition were revealed. It was determined, that the number of capillaries and neurons decreased with the age and number of glial cells increased.